PNC 27
PNC {{{{}}}}}}}}}}}}}}} Puas muaj hluav taws xob bigeric peptide tsim los xaiv kev tuag hauv cov qog nqaij hlav cancer hauv cov kabmob hlwb. Nws yog tsim ntawm P53 {{5} deriving HDM2 {} Daim phiaj yog cov khoom siv qog nqaij hlav cancer. Nws cov kev siv tshuab yog qhov sib txawv ntawm cov tshuaj khomob, ua rau muaj kev sib tuag tsis meej, cov txheej txheem piav qhia tias 'poptosis' (pore-ua rau necrosis).
PNC {{{{}}}}}}}}}}}}}}} Puas muaj hluav taws xob bigeric peptide tsim los xaiv kev tuag hauv cov qog nqaij hlav cancer hauv cov kabmob hlwb. Nws yog tsim ntawm P53 {{5} deriving HDM2 {} Daim phiaj yog cov khoom siv qog nqaij hlav cancer. Nws cov kev siv tshuab yog qhov sib txawv ntawm cov tshuaj khomob, ua rau muaj kev sib tuag tsis meej, cov txheej txheem piav qhia tias 'poptosis' (pore-ua rau necrosis).
Tshuaj & Cov Ntaub Ntawv Ntaub Ntawv
• Tus lej lej: 1159861-00-3
• Cov qauv: 32-amino acid brecericic peptide
• Thawj: P53 cov seem (HDM2 {{{{{} binding) + antennapedia / Penetratin (Penetratin (Coretratin (Coretatin)
• HOM PHIAJ: MEMBRANE - pars hdm2 hauv cov qog nqaij hlav cancer
• Nkeem: Daim ntawv pores → lysis ntawm cov qog hlwb (p53 ywj siab)
• Tsos: Hmoov: Labophilized hmoov, loj dua los yog sib luag rau 98% kev coj dawb huv
• Cia: -20 degree, qhuav, tsis txhob khov -} thahaw cycles
Kev Tshawb Fawb & Kev Siv Cancer
• Ua kom cov neeg mob cancer sib txawv: cov kab mob qog noj ntshav: mob rwj, mis, pancreatic, melanoma, zes qe menyuam.
• Xaiv: spares li fibroblasts thiab cov hlwb endothelial yam tsis muaj daim nyias nyias HDM2.
• Kev Tshawb Nrhiav: Electron tsom iav pom zoo tshaj tawm cov khoom lag luam hauv cov qog hauv cov qog.
• EX Vivo: Pom tau CytoToxicity nyob rau hauv Thawj Zaug Ovarian Cancer Cancer.
• Cov Qauv Tsiaj: Cov Qog Hluav Taws Xob Kev Tshaj Tawm tau tshaj tawm hauv xenografts nrog tsawg heev ntawm qhov system toxicity.
• Cov tshuab ua haujlwm: ua haujlwm ntawm nws tus kheej ntawm P53 kev sib hloov.
Kev Nyab Xeeb & Kev Cai Cai Sau Ntawv
- FDA CEEB TOOM: Qhia tawm tsam PNC-27 ua rau kev kho mob cancer (2017).
- Cov kev tsis zoo: Cov hemorresage Gi hemorrhage nyob rau hauv cov ntaub ntawv qhia.
- Cov kev pheej hmoo: Tib neeg koob tshuaj, toxicology, ntev - TSHEM UAS tsis paub.
- Cov kev txhawj xeeb khoom: Cov khoom hauv online yuav muaj kev ua kom peptide peptide.
Kev Siv Cov Lus Taw Qhia
• Daim ntawv: Raug muab raws li Lyophilized peptide hmoov; Rov qab siv nrog cov dej tsis muaj zog / cov kab mob.
• Txoj kev xa khoom: hauv vitro (daim ntawv thov ncaj qha rau kev coj noj coj ua), hauv Vivo (qhov system txhaj hauv tsiaj xenografts).
• Kev txhaj hauv zej zog: subcutaneing txhaj tau hais (0.3-1 mg), tsis muaj kev hloov pauv thiab tsis nyab xeeb.
• Muaj kev pab cuam: tsis muaj qauv tib neeg txoj kevcai lij choj. Qee qhov kev xav txog ntawm txhua hnub / mus txog txhua lub lim tiam, tab sis tsis txhawb kev kawm tau.
• Ntaus: Qee zaum tham nrog kev siv tshuaj kho mob lossis kev kho mob tiv thaiv kab mob, tab sis tsuas yog kev xav.
Tseem ceeb: Tsis muaj kev txhaj tshuaj tiv thaiv kev saib xyuas; FDA ceeb toom tawm tsam kev siv tshuaj.
Piv: PNC-27 VS FOXO4-DRI VS NOOB-3
|
Yam zoo |
PVNC-27 |
Foxo4-dri |
Nutlin-3 |
|
Lub tshuab |
Binds HDM2 hauv cov ntaub nyias nyias, cov ntaub ntawv pores → necrosis |
Thaiv Foxo4-P53 → Apoptosis ntawm SenescTube |
Thaiv MDM2-PDM2-PDM2 → Kev Ua P53 |
|
Phiaj Xwm |
Cancer hlwb nrog membrane HDM2 |
Senescent cells (anti -} kev laus / kev tshawb fawb fibrosis) |
MDM2 {{-} Cov qog nqaij hlav cawb tawm nrog cov tsiaj qus hom p53 |
|
Yam povthawj |
Cell, Ex Vivo, Kev Tshawb Fawb Tsiaj |
Cell & nas kev tshawb fawb nkaus xwb |
Cov chaw kho mob sib tw hauv kev sim siab |
|
Kev txwv |
FDA ceeb toom FDA; Cov ntaub ntawv qhia txog kev ua phem |
Sim; tib neeg kev nyab xeeb tsis paub |
Toxicities; nyob ntawm qog nqaij p53 xwm txheej |
FAQ - pnc-27
** Q1: Yog PC-27 A Cancer Kho Mob? **
Tsis tau. Nws tseem nyob rau hauv kev tshawb fawb ua ntej nkaus xwb.
** Q2: Nws tua cov qog nqaij hlav? **
Los ntawm Binding HDM2 hauv cov nyias nyias thiab kev tsim cov hws, ua rau necrosis.
** Q3: Puas yog ua haujlwm ntawm P53-Mutant Cancers? **
Yog, mechanism yog P53 ywj siab.
** Q4: Puas muaj kev nyab xeeb Dosing raws tu qauv? **
Tsis tau. Txhua tus tib neeg cov ntaub ntawv tshaj tawm yog Anecdotal thiab tsis muaj kev hloov pauv.
** Q5: Puas muaj rau cov neeg mob? **
Tsis tau. Nws yog kev tshawb fawb peptide nkaus xwb; FDA hais lus ceeb toom rau kev siv.
Kev Muaj Peev Xwm Zoo
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Cim npe nrov: PNC 27, Suav PNC 27 Cov Chaw Tsim Tshuaj, Cov Chaw Muag Khoom
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